T8785
Thyrotropic hormone from porcine pituitary
5 IU/mg
Synonym(s):
TSH, Thyroid stimulating hormone
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About This Item
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biological source
Porcine pituitary glands
Quality Level
form
powder
specific activity
5 IU/mg
packaging
vial of 10 IU
technique(s)
cell culture | mammalian: suitable
shipped in
ambient
storage temp.
2-8°C
Gene Information
human ... TSHR(7253)
pig ... TSH-BETA(397658)
Application
Thyrotropic hormone from porcine pituitary can be used as a NCTC-135 medium supplement for isolating the thyroid cells which in turn is used for studying the impact of retinoids on non-transformed cells like thyrocytes.[1] The product can also be used in cell proliferation experiment for studying the impact of increased IGF binding proteins 1 level on the function and growth of the thyroid gland in transgenic mice.[2]
Biochem/physiol Actions
Thyrotropic hormone also referred to as Thyrotropin or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.[3] It modifies EGF receptor function in porcine thyroid follicle cells through a cAMP-dependent process and increases the generation of inositol 1,4,5-trisphosphate in human thyroid cells.[4][5]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributedto the β-chain.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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T Modric et al.
European journal of endocrinology, 141(2), 149-159 (1999-07-31)
IGF-I, IGF-I receptor and IGF-binding proteins (IGFBPs) are expressed in thyroid tissue and are associated with the function and growth of the thyroid. This study investigated the in vivo and in vitro effects of increased IGFBP-1 levels on the function
E Fröhlich et al.
The Histochemical journal, 33(5), 295-304 (2001-09-21)
The purpose of the paper was to study the morphological effects of retinoids on non-transformed cells such as thyrocytes. The formation of follicles was studied in primary cultures of porcine thyrocytes by adding retinol and thyroid stimulating hormone (TSH) to
K Westermark et al.
Molecular and cellular endocrinology, 40(1), 17-23 (1985-04-01)
Porcine thyroid follicle cells in monolayer cultures were shown to contain one single class of high-affinity EGF receptors with Kd = 4.5 X 10(-10) M and approximately 20 000-25 000 receptors per cell. Suspension cultures of aggregated follicle cells, exposed
Shi Chen et al.
Kardiologia polska, 71(2), 143-151 (2013-04-12)
Impaired left ventricular (LV) diastolic function is a common pathophysiological feature of patients with hypertrophic cardiomyopathy (HCM). High-normal thyrotropin (thyroid-stimulating hormone, TSH) levels may alter the performance of the left ventricle. To ascertain whether the severity of impaired LV diastolic
Uğur Ünlütürk et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2210-2217 (2013-04-05)
An increased or normal serum TSH concentration, despite elevated thyroid hormone levels, is observed in resistance to thyroid hormone (RTH) and TSH-secreting adenomas (TSHomas). When coexistent with a differentiated thyroid cancer (DTC), maintenance of a suppression of TSH is challenging.
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