TAK1 is an orphan nuclear receptor that represses the transcription of Gata1 and also inhibits signal transduction via T3R, RAR and RXR pathways. This orphan receptor also regulates PPARα-mediated gene expression in liver cells . Anti-TAK1 antibody recognizes TAK1 (70 kDa). Additional unidentified bands may be detected.
Immunogen
synthetic peptide corresponding to amino acids 588-606 of human TAK1. The sequence is identical in mouse and Xenopus.
Application
Anti-TAK1 antibody is suitable for use in immunoblot (using whole-cell extracts from control MDA-MB-231 cells and MDA-MB-231 cells expressing shRNA to TAK1 ). The product can also be used for immunoprecipitation (1 μg using RIPA lysate (1 mg) from 3T3/HIR cells).
Physical form
Solution in 0.1 M Tris-glycine buffer, pH 7.4, containing 150 mM sodium chloride, 0.05% sodium azide
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Recently, we reported the cloning and characterization of the novel orphan receptor TAK1. In this study, we analyze the interaction of TAK1 with a variety of response elements (RE's) and demonstrate that TAK1 binds effectively to RE's composed of the
The Journal of biological chemistry, 273(18), 10948-10957 (1998-06-06)
Recently, we reported the cloning of the nuclear orphan receptor TAK1. In this study, we characterized the sequence requirements for optimal TAK1 binding and analyzed the repression of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway by TAK1. Site selection
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