T7040

Tyrphostin 1

≥98%

• Synonym(s): (4-Methoxybenzylidene)malononitrile
• Linear Formula: CH₃OC₆H₄CH=C(CN)₂
• CAS Number: 2826-26-8
• Molecular Weight: 184.19
• MDL number: MFCD00019787
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278751
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥98%
• form: solid
• potency: >1250 μM IC₅₀ (negative control)
• mp: 113-116 °C (lit.)
• solubility: chloroform: soluble 50 mg/mL, clear, light yellow; DMSO: soluble
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)\C=C(/C#N)C#N
• InChI: 1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
• InChI key: UOHFCPXBKJPCAD-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956)

Description

Application

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells[1].

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation[2],[3]. Furthermore, studies have reported that tyrphostin 1 can block Ca²⁺ channels and inhibit growth in vascular smooth muscle cells[4],[5].

Features and Benefits

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Preparation Note

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)