T6576

L-Theanine

• Synonym(s): N_γ-Ethyl-L-glutamine, L-Glutamic acid γ-(ethylamide), Suntheanine
• Empirical Formula (Hill Notation): C₇H₁₄N₂O₃
• CAS Number: 3081-61-6
• Molecular Weight: 174.20
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900389
• EC Number: 221-379-0
• MDL number: MFCD00059653

Properties

• SMILES string: CCNC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
• InChI key: DATAGRPVKZEWHA-YFKPBYRVSA-N

Description

Biochem/physiol Actions

Theanine is able to bind to AMPA, kainite, and NMDA glycine receptors in rat cortical neurons but with less affinity than glutamic acid. It has been studied as a glutamate transport inhibitor, preventing glutamate uptake by M5076 ovarian sarcoma-bearing mouse cells and increasing the effect of doxorubicin on tumor growth in M5076 mice.

Other Notes

Theanine is an amino acid analog of glutamine, found in green tea.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves