Trap-101 Hydrochloride is a nociceptin/orphanin FQ peptide (NOP) receptor blocker.
Trap-101 Hydrochloride is a nociceptin/orphanin FQ peptide (NOP) receptor blocker. Trap-101 acts as an inverse agonist. Trap-101 had been found to be an effective NOP receptor antagonist both in vitro and in vivo, with equivalent potency to J113397.
Frontiers in aging neuroscience, 5, 52-52 (2013-09-26)
The DBA/2J mouse is a model of pigmentary glaucoma in humans as it shows age-related increases in intraocular pressure (IOP), retinal ganglion cell death and visual impairment. Previously, we showed that visual ability declines from 9 to 12 months of
Menopause (New York, N.Y.), 21(5), 493-500 (2013-09-26)
Melatonin synthesis and secretion are partly modulated by estrogen and progesterone. Changes in melatonin concentrations, possibly related to the menopausal transition, may be associated with climacteric mood, sleep, and vasomotor symptoms. The aims of this study were to compare the
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 31(9), 690-692 (2013-09-26)
To investigate the genotoxicity and oxidative stress induced by copper oxide nanoparticles in mice. Thirty mice were randomly divided into control group and low- and high-dose exposure groups. The low- and high-dose exposure groups were given copper oxide nanoparticles (50
Annals of Saudi medicine, 33(4), 356-362 (2013-09-26)
The trial of labor after previous cesarean (TOLAC) is an important strategy to limit repeat cesarean sections and their complications. An unsuccessful TOLAC leads to maternal and neonatal morbidities. The success or failure of TOLAC after the first cesarean is
Cancer chemotherapy and pharmacology, 72(5), 1111-1123 (2013-09-26)
The aim of this study was to describe the nonlinear pharmacokinetics of total and unbound plasma cisplatin under different administered time in patients with non-small-cell lung carcinoma. Patients receiving chemotherapy with cisplatin were included in this analysis. Patients were divided
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