T5819

TRAIL Receptor 2/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

• Synonym(s): DR5, MK, TRICK2
• MDL number: MFCD01867160
• UNSPSC Code: 12352200

Properties

• recombinant: expressed in baculovirus infected Sf21 cells
• assay: >95% (SDS-PAGE)
• form: lyophilized powder
• mol wt: ~49 kDa by SDS-PAGE (reducing); calculated mol wt ~40 kDa
• impurities: endotoxin, tested
• UniProt accession no.: Q9QZM4
• storage temp.: −20°C
• Gene Information: mouse ... Tnfrsf10b(21933)

Description

Application

TRAIL Receptor 2/Fc Chimera from mouse was used to study apoptosis induced by acetyl-keto-beta-boswellic acid isolated from Boswellia carterri and Boswellia serrata in prostate cancer cells via death receptor 5-mediated pathway.[1]

Biochem/physiol Actions

Member of the TNFR superfamily that binds TRAIL and induces apoptosis in a variety of cell types.

Member of the TNFR superfamily that binds TRAIL and induces apoptosis in a variety of cell types. The degree of homology between the death domains of mouse TRAIL R2 and either human TRAIL R1 or TRAIL R2 is 76% and 79%, respectively.

TRAIL Receptor 2 also refers as DR5 or TRICK2 belongs to TNF receptor family and can induce apoptosis via FADD and caspase-8. It also promotes NF-κ-B activation.[2]

Other Notes

Extracellular domain of mouse TRAIL R2 (a.a. 1-177) fused to the C-terminal Fc region of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

Inhibits apoptosis of mouse L929 cells treated with 20 ng/ml recombinant human TRAIL or 12 ng/ml cross-linked recombinant human TRAIL.