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T5818

Sigma-Aldrich

Tyrphostin AG 974

≥98%, solid

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About This Item

Empirical Formula (Hill Notation):
C10H5IN2O2
CAS Number:
Molecular Weight:
312.06
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98%

form

solid

color

orange-brown

solubility

DMSO or ethanol: soluble

storage temp.

−20°C

Biochem/physiol Actions

Tyrphostin AG 974 is an EGFR protein tyrosine kinase inhibitor. Studies have reported that AG-974 can induce cell death in fibrosarcoma cell lines1.

Preparation Note

Tyrphostin AG 974 is soluble in DMSO or ethanol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Sarit Bendetz-Nezer et al.
Molecular pharmacology, 66(3), 627-634 (2004-08-24)
DNA topoisomerases (topo) are the cellular targets of several anticancer drugs used today in the clinic. Our previous work demonstrated that certain tyrphostin derivatives, known as protein tyrosine kinase antagonists, are catalytic inhibitors of DNA topoisomerases I (topo I) in

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