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T5455

Sigma-Aldrich

TAT-JBD trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2 trifluoroacetate, TAT-TI-JIP153–163 trifluoroacetate, YGRKKRRQRRRRPKRPTTLNLF trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C125H220N52O27 · xC2HF3O2
Molecular Weight:
2883.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥95% (HPLC)

form

lyophilized solid

storage condition

desiccated
protect from light

color

white

solubility

H2O: >1 mg/mL

storage temp.

−20°C

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2

Biochem/physiol Actions

TAT-JBD can decrease 1-methyl-4-phenylpyridinium ion (MPP(+))-induced caspase-9 stimulation in rat cells1.
TAT-JBD is a cell-permeable JNK inhibitor.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TAT-JBD trifluoroacetate salt is soluble in water at a concentration that is greater than 1 mg/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
120M4705V

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Stéphanie Pain et al.
Toxicology, 243(1-2), 124-137 (2007-11-27)
Many studies showed that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which was widely used to produce Parkinson's disease (PD)-like models in animals can elicit apoptosis with increase of caspase activity via its neurotoxic metabolite 1-methyl-4-phenylpyridinium ion (MPP(+)). Another pathway shown in MPTP-mediated nigrostriatal dopaminergic

Articles

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

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