T5077
Tissue Factor Proteinase Inhibitor-II
recombinant, expressed in Nicotiana (tobacco), ≥97% (SDS-PAGE)
Synonym(s):
TFPI-2
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C407H592N116O117S6
Molecular Weight:
9174.15
UNSPSC Code:
12352204
NACRES:
NA.77
Recommended Products
recombinant
expressed in Nicotiana (tobacco)
assay
≥97% (SDS-PAGE)
form
solid
mol wt
~_9.2 kDa
storage temp.
−20°C
General description
First Kunitz domain of TFPI-II containing a lysine residue at position 24
Biochem/physiol Actions
Protease inhibitor of metastasis and angiogenesis
Protease inhibitor of metastasis and angiogenesis. Hypermethylation of the TFPI-2 gene causes transcriptional silencing in choriocarconoma cells. The TFPI-2 gene may be a candidate tumor suppressor gene.[1]
Unit Definition
One trypsin unit will produce a ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 ml, 1 cm light path.
Preparation Note
Soluble in water (0.5mg/ml) and in aqueous buffers of low ionic strength
Analysis Note
One mg will inhibit ≥1.3 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Florent Hubé et al.
Biological chemistry, 384(7), 1029-1034 (2003-09-06)
Tissue factor pathway inhibitor-2 (TFPI-2), a Kunitz-type serine proteinase inhibitor associated with the extracellular matrix, has been shown to reduce tumor invasion. In the present study we identified the presence of a complete CpG island region spanning exon 1 and
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
