T3326
Tamapin
recombinant, expressed in E. coli, ≥95% (HPLC), lyophilized powder
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
recombinant
expressed in E. coli
Quality Level
assay
≥95% (HPLC)
form
lyophilized powder
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Ala-Phe-Cys-Asn-Leu-Arg-Arg-Cys-Glu-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Glu-Glu-Cys-Lys-Cys-Val-Pro-Tyr
Biochem/physiol Actions
Member of the α-5.4 scorpion toxin family. Blocks KCa2 channels with selectivity for KCa2.2 versus KCa2.1 channels.
Tamapin strongly associates with Ca(2+)-activated K(+) (SK) channels and blocks SK-channel mediated currents in hippocampal neurons1.
Preparation Note
A stock solution of 1 μM can be prepared by adding 0.289 ml of any conventional buffer per μg of peptide.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Paola Pedarzani et al.
The Journal of biological chemistry, 277(48), 46101-46109 (2002-09-20)
The biophysical properties of small conductance Ca(2+)-activated K(+) (SK) channels are well suited to underlie afterhyperpolarizations (AHPs) shaping the firing patterns of a conspicuous number of central and peripheral neurons. We have identified a new scorpion toxin (tamapin) that binds
Ricardo C Rodríguez de la Vega et al.
Toxicon : official journal of the International Society on Toxinology, 43(8), 865-875 (2004-06-23)
Much of our knowledge on K+-channels was elucidated using specific peptide ligands isolated from a number of venomous organisms. Recently, this field received a strong support and increased interest due to the solution of the three-dimensional structure of a couple
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
