T3301
Transforming Growth Factor-β1 Receptor II Soluble Fragment human
≥97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder
Synonym(s):
TGF-β1 RII
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About This Item
recombinant
expressed in mouse NSO cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
impurities
endotoxin, tested
storage temp.
−20°C
General description
Transforming growth factor-β (TGF-β) belongs to the TGF-β superfamily of secreted proteins. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β acts through binding to three transmembrane receptors in mammals, type I, type II and type III receptors. [1] It is expressed by most cell types and regulates the DNA-binding activity of transcription factors. [2]The important pathways regulated by TGF-β are the SMAD, BMP, MAPK and PI3K/Akt pathways.[3][4] [5]TGF-β is involved in cell and tissue differentiation, proliferation, morphogenesis, secretion of metalloproteases and inflammation. Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression[2][6]
Recombinant, human TGF-β1 soluble receptor II will bind to TGF-β1, -β2, -β3, and -β5.
Recombinant, human TGF-β1 soluble receptor II will bind to TGF-β1, -β2, -β3, and -β5.
Application
Recombinant, human TGF-β1 sRII may be used to inhibit TGF-β1 activity on mouse T cell line, HT-2.
Physical form
Lyophilized from 0.2 μm filtered phosphate buffered saline containing 1.25 mg bovine serum albumin
Analysis Note
The receptor mediated activity of human TGF-β1 receptor II soluble fragment is measured by its ability to inhibit the TGF-β1 bioactivity in HT-2 cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Justin P Annes et al.
Journal of cell science, 116(Pt 2), 217-224 (2002-12-17)
TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta from its latent state. The unusual temporal discontinuity of TGFbeta synthesis and action and the panoply
Rik Derynck et al.
Nature, 425(6958), 577-584 (2003-10-10)
Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this
Pinglong Xu et al.
FEBS letters, 586(14), 1871-1884 (2012-05-24)
TGF-β family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads. Nevertheless, TGF-β family proteins induce highly complex programs of gene
Joan Massagué et al.
FEBS letters, 586(14), 1953-1958 (2012-06-20)
The canonical TGF-β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical
Receptors for the TGF-beta family.
J Massagué
Cell, 69(7), 1067-1070 (1992-06-26)
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