T2440
Anti-Tumor Necrosis Factor Soluble Receptor II antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-TNF sRII
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Tnf(21926) , Tnfrsf1a(21937) , Tnfrsf1b(21938)
General description
Tumor Necrosis Factor Receptor II (TNF RII) is a 75kD transmembrane glycoprotein expressed mainly on endothelial cells, macrophages, Langerhans cells and monocytes. It has a crucial role in regulating TNF α function by antagonizing its biological activity that is by blocking TNF-α-induced apoptosis. Anti-Tumor Necrosis Factor Soluble Receptor II (TNF sRII) antibody can be used in western blotting. Goat anti-Tumor Necrosis Factor Soluble Receptor II antibody reacts specifically with mouse TNF sRII. This antibody has also shown less than 15% cross-reactivity for recombinant human TNF-sRII.
Specificity
The antibody detects mouse TNF RII and shows <15% cross-reactivity with recombinant human TNF sRII.
Immunogen
recombinant mouse TNF soluble receptor II (TNF sRII) expressed in Escherichia coli.
Application
Anti-Tumor Necrosis Factor Soluble Receptor II (TNF sRII) antibody can be used in indirect ELISA.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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E Lien et al.
European journal of immunology, 25(9), 2714-2717 (1995-09-01)
Lipopolysaccharide (LPS), a part of the Gram-negative bacteria cell wall, is a potent inducer of tumor necrosis factor (TNF). TNF is an important mediator in Gram-negative infections such as meningococcal septic shock, but its harmful action can be prevented by
J R Bradley et al.
The American journal of pathology, 146(1), 27-32 (1995-01-01)
We have used confocal immunofluorescence microscopy and immunogold electron microscopy to localize tumor necrosis factor (TNF) receptors in cultured human umbilical vein endothelial cells. The 75-kd receptor is largely expressed on the cell surface and undergoes endocytosis and transport to
B Wang et al.
Immunology, 88(2), 284-288 (1996-06-01)
Langerhans' cells (LC) represent the major antigen-presenting cells within the epidermis. Following exposure of the skin to antigen, LC take up antigen, migrate into draining lymph nodes (DLN) and present processed antigen to T lymphocytes, thereby initiating an immune response.
Begoña Lainez et al.
International immunology, 16(1), 169-177 (2003-12-23)
Tumor necrosis factor (TNF)-alpha is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation, differentiation and cell death induction in several cell types. The biological effects of TNF-alpha are mediated via the cell-surface TNF
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