T2400
Tropomyosin from porcine muscle
lyophilized powder (contains Tris buffer salts)
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1 MG
$175.75
$175.75
List Price$185.00Save 5%Web-Only Promotion
Available to ship onApril 29, 2025Details
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1 MG
$175.75
About This Item
$175.75
List Price$185.00Save 5%Web-Only Promotion
Available to ship onApril 29, 2025Details
Recommended Products
biological source
Porcine muscle
Quality Level
assay
≥70% protein basis (biuret)
form
lyophilized powder (contains Tris buffer salts)
technique(s)
electrophoresis: suitable
storage temp.
−20°C
Related Categories
General description
Tropomyosin is a member of the actin filament binding protein family.[1] It is a ubiquitous protein present in animals and fungi.[2] Tropomyosin is made up of two α-helical chains arranged as a coiled-coil. It exists over twenty isoforms,[3] in different eukaryotic cells like skeletal, cardiac, and smooth muscles, brain, platelets, fibroblasts, platelets, and other non-muscle cells.[4]
Application
Biochem/physiol Actions
Dimeric protein that assumes an α-helical coiled coil conformation. In the absence of Ca2+, inhibits muscle contractility by blocking the myosin binding sites on actin.
Tropomyosin is associated with the actin cytoskeleton and plays a role in stabilizing and regulating the interactions of actin with other actin-binding proteins. It also plays a role in muscle contraction by regulating the interactions of actin with myosin.[2]
Tropomyosin together with troponin, regulates the binding of myosin to actin. Tropomyosin is a dimeric coiled-coil protein forming continuous polymers along the myosin-binding groove of actin. Various tropomyosin isoforms help confer structure and function to actins in the cytoskeleton and striated muscle function. Dimeric protein that assumes an α-helical coiled-coil conformation. In the absence of Ca2+, it inhibits muscle contractility by blocking the myosin binding sites on actin.
Analysis Note
SDS electrophoresis shows two major bands.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Vertebrate tropomyosin: distribution, properties and function
Perry S V, et al.
Journal of Muscle Research and Cell Motility, 5?49-5?49 (2001)
A systematic nomenclature for mammalian tropomyosin isoforms
Michael A G, et al.
Journal of Muscle Research and Cell Motility, 147?153-147?153 (2015)
The molecular basis for tropomyosin isoform diversity
James P L M, et al.
Bioessays (1991)
A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding
Judith B A, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1833(4), 833-839 (2013)
G Reese et al.
International archives of allergy and immunology, 119(4), 247-258 (1999-09-04)
Among food allergens, crustaceans, such as shrimp, crab, crawfish and lobster, are a frequent cause of adverse food reactions in allergic individuals. The major allergen has been identified as the muscle protein tropomyosin. This molecule belongs to a family of
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