SRP8031

FNDC5

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

• Synonym(s): Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• recombinant: expressed in E. coli
• conjugate: untagged
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~16 kDa
• packaging: pkg of 10 μg
• impurities: <0.01 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: Q8NAU1
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... FNDC5(252995)

Description

General description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

FNDC5 (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable