SRP6563

BrdT (257-382) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonym(s): CT9, Cancer/testis antigen 9, RING3-like protein
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥98% (SDS-PAGE)
• form: liquid
• mol wt: 14.9 kDa (126 aa, 257-382 aa + NT His Tag)
• packaging: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• NCBI accession no.: NM_207189
• UniProt accession no.: Q58F21
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... BRDT(676)

Description

General description

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. It may play a role in the transcriptional regulation of spermatogenesis. It also seems to have a structural ATP-independent role in the reorganization of acetylated chromatin. Therecombinant protein includes Bromo 1 domain (257-382 aa) with N-terminal His-tag.

Physical form

rh-BrdT is supplied as a solution in 50 mM Tris, pH 8.0, 150 mM NaCl and 10% Glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable