SRP6530

NMNAT1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Synonym(s): EC 2.7.7.1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1, Nicotinamide Mononucleotide Adenylyl-transferase 1
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: liquid
• mol wt: monomer ~333 kDa (Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag.)
• packaging: pkg of 10 and 50 μg
• concentration: 1 mg/mL
• UniProt accession no.: Q9HAN9
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... NMNAT1(64802)

Description

General description

This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.

Physical form

1 mg/mL in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable