SRP6521
Ubiquitin-Fluorescein-labeled (FLR-Ub)
≥95% (SDS-PAGE)
Synonym(s):
CEP80, HUBCEP80, RPS27A, Ribosomal Protein S27a, UBA80, UBB, UBCEP1, UBCEP80
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
9.009 kDa
packaging
pkg of 50 μg
concentration
8 mg/mL
shipped in
dry ice
storage temp.
−70°C
General description
Post-translational modification of proteins by ubiquitin (Ub) is a key regulatory process that impacts almost all cellular functions. Apart from the established role of Ub in protein degradation, it is implicated in cell signaling, DNA damage response, protein trafficking, cell-cycle progression, inflammation, immune response and regulation of apoptosis. Ubiquitylation occurs through isopeptide linkage between the C-terminus of Ub and the e-amino group of a lysine (Lys) residue on the target substrate. Ub itself has seven Lys residues (6, 11, 27, 29, 33, 48, and 63), any of which can participate in further ubiquitylation, generating polyUb chains. Monitoring the ubiquitylation of target proteins or the growth of polyubiquitin chains has traditionally been carried out with either radiolabeled or epitope-tagged ubiquitin requiring long and laborious detection methods. Fluorescently labeled ubiquitin provides a rapid, facile technique for studying ubiquitin conjugation in vitro. Unlike others, Thefluorescein-labeled ubiquitin carries a single fluorescein molecule attached at a defined location and avoids modification of either the N-terminus or Lys side chains.
Biochem/physiol Actions
Ribosomal protein S27a (RPS27a) plays a major role in ribosome biogenesis and post-translational modifications of proteins. It also stimulates proliferation, modulates cell cycle and prevents apoptosis of leukemia cells.[3]
Physical form
≥ 8 mg/mL in PBS.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Systemic analysis of the differential gene expression profile in a colonic adenoma- normal SSH library
Lu B, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 378(1-2), 42-47 (2007)
Identification and expression of MMSA-8, and its clinical significance in multiple myeloma.
He R, et al.
Oncology Reports, 37(6), 3235-3243 (2017)
RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells.
Wang H, et al.
Biochemical and Biophysical Research Communications, 446(4), 1204-1210 (2014)
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