SRP6503

Notch-1 from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Synonym(s): Neurogenic Locus Notch Homolog Protein 1, Notch A, mT14, p300
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: mouse
• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: calculated mol wt ~85.0 kDa
• packaging: pkg of 25 μg
• impurities: <0.1 EU/μg endotoxin (LAL test)
• UniProt accession no.: Q01705
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... NOTCH1(18128)

Description

General description

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

The extracellular domain of mouse Notch-1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats)

Physical form

Lyophilized with PBS.

Reconstitution

Reconstitute with sterile water to 1 mg/mL.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable