SRP6363

KLRB1 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Synonym(s): CD161, CLEC5B, Killer cell lectin-like receptor subfamily B member 1, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥85% (SDS-PAGE)
• form: liquid
• mol wt: 21 kDa (183 aa, 67-225 aa + His Tag)
• packaging: pkg of 100 μg
• concentration: 1 mg/mL
• UniProt accession no.: Q12918
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... KLRB1(3820)

Description

General description

Killer cell lectin-like receptor subfamily B member 1, also known as KLRB1, plays an inhibitory role on natural killer (NK) cells cytotoxicity. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. Recombinant human KLRB1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable