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Key Documents

SRP6358

Sigma-Aldrich

CXCL4 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonym(s):

Chemokine (C-X-C motif) ligand 4, MGC138298, PF4, SCYB4

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥85% (SDS-PAGE)

form

liquid

mol wt

10 kDa (91 aa, 32-101 aa + His Tag)

packaging

pkg of 20 μg

concentration

0.25 mg/mL

UniProt accession no.

P02776

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CXCL4(5196)

General description

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets.[1] Recombinant human CXCL4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Biochem/physiol Actions

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various negatively charged proteoglycans.[1][2]

Physical form

0.25 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 2 mM DTT and 50% glycerol.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Tiago Carvalheiro et al.
Frontiers in immunology, 11, 1793-1793 (2020-09-26)
Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands.
Kai Huang et al.
Annals of palliative medicine, 9(5), 2723-2730 (2020-09-22)
Chronic osteomyelitis is associated with the immune suppression. CD4(+)CD25(+) FOXP3(+) regulatory T cells (Tregs) play a key role in the peripheral tolerance to prevent immune responses to self-antigens and allergens. Evidence has suggested that the accumulation and activity of Tregs
Roberto Lande et al.
International journal of molecular sciences, 21(14) (2020-07-28)
Systemic sclerosis (SSc) is characterized by skin/internal organ fibrosis, vasculopathy and autoimmunity. Chemokine (C-X-C motif) ligand 4 (CXCL4) is an SSc biomarker, predicting unfavorable prognosis and lung fibrosis. CXCL4 binds DNA/RNA and favors interferon (IFN)-α production by plasmacytoid dendritic cells
CXCL4 Plasma Levels Are Not Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology.
Erbel C
PLoS ONE, 10(11), e0141693-e0141693 (2015)
Transformation-associated cytokine 9E3/CEF4 is chemotactic for chicken peripheral blood mononuclear cells.
Barker KA
Journal of Virology, 67(6), 3528-3533 (1993)

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