SRP6345

TNFSF8 human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonym(s): CD153, CD30L, CD30LG, tumor necrosis factor ligand superfamily member 8
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: liquid
• mol wt: 22 kDa (195 aa, 63-234 aa + His Tag)
• packaging: pkg of 50 μg
• concentration: 0.5 mg/mL
• UniProt accession no.: P32971
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... TNFSF8(944)

Description

General description

TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin′s and some non-Hodgkin′s lymphomas. Recombinant human TNFSF8 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Physical form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol and 0.4 M Urea.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable