Interferon regulatory factor (IRF) 2 is a member of the interferon regulatory transcription factor family. IRF-2 is generally regarded as an oncoprotein. Structure of IRF1 and IRF2 are similar. However, its functions are different. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons α and β, and presumably other genes that employ IRF1 for transcription activation. Recombinant human IRF2 was expressed in E.coli and purified by using conventional chromatography techniques.
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1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT and 10% glycerol.
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish.
Krishnan, et al.
Nature Genetics, 54, 684-693 (2022)
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