SRP6331

CD5 human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonym(s): LEU1, T-cell surface glycoprotein CD5, T1
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: liquid
• mol wt: 41 kDa (371 aa, 25-372 aa + His tag)
• packaging: pkg of 50 μg
• concentration: 1 mg/mL
• impurities: <1 EU/μg endotoxin (LAL test)
• UniProt accession no.: P06127
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CD5(921)

Description

General description

CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.[1]
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli.

Biochem/physiol Actions

CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns.[2] In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor.[3] CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus.[2] In infants, high levels of CD5⁺ cells suggest the risk of development of allergic disease.[4] The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).[5][6]

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable