SRP6295
IL-1 Alpha human
recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
Synonym(s):
IL-1α, IL-1A, IL1, IL1 ALPHA, IL1-ALPHA, IL1A, IL1F1, Interleukin, Interleukin-1 alpha
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in HEK 293 cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
mol wt
calculated mol wt 18.0 kDa (no tag)
observed mol wt 22 kDa by SDS-PAGE (DTT-reduced.)
packaging
pkg of 10 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL-1a(3552)
General description
Interleukin-1α (IL1α) is also known as IL-1A, IL1, IL1-α, IL1F1, and is a cytokine of the interleukin-1 family. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum. The gene encoding this protein is localized on human chromosome 2.[1][2]
Biochem/physiol Actions
Interleukin-1α (IL1α) possesses a wide spectrum of metabolic, physiological, hematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor.[3] The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.
Physical form
Lyophilized from 0.22 μm filtered solution in in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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