SRP6179
Procathepsin K human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
CTSK, CTSO, CTSO3
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About This Item
UNSPSC Code:
12352200
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biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
35.9 kDa
packaging
pkg of 1 mg
pkg of 50 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CATK(1513)
General description
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
Physical form
1 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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