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SRP6165

Sigma-Aldrich

M-CSF human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(s):

CSF-1, Lanimostim, MGC31930, Macrophage colony stimulating factor 1

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About This Item

CAS Number:
81627-83-0
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

(35 and 40 kDa, homodimer, glycosylated)

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

NCBI accession no.

P09603

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CSF1(1435)

General description

Granulocyte/macrophage colony-stimulating factors (MCSFs) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.

Biochem/physiol Actions

The gene encoding macrophage colony-stimulating factor (MCSF) is located on human chromosome 1p13.3. It is a glycosylated polypeptide which exists as a homodimer.[1][2]

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number
9F186455

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Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha OM
Nature Genetics, 42(6), 520-524 (2010)
Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.
Rettenmier CW
Molecular and Cellular Biology, 7(7), 2378-2387 (1987)

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