SRP6067
Cyclophilin D human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
CYP-40, CYPD, PPID, Peptidyl prolyl isomerase D
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
42.9 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PPID(5481)
General description
Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP).
Application
Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.
Biochem/physiol Actions
Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.
Physical form
1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D
Kristina Csukly
The Journal of Physiology (2006)
Giuseppe Federico Amodeo et al.
International journal of molecular sciences, 22(20) (2021-10-24)
The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c subunit from mammalian mitochondria exhibits ion channel activity. In particular, c
Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.
Peng JZ
Genetics and molecular research : GMR, 14(2), 4258-4268 (2015)
Jeejabai Radhakrishnan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2734-2748 (2015-04-04)
Cyclophilin-D (Cyp-D) is a mitochondrial matrix peptidyl-prolyl isomerase. Because cyclophilins can regulate nuclear gene expression, we examined whether Cyp-D could regulate mitochondrial gene expression. We demonstrated in HEK 293T cells that transfected Cyp-D interacts with mitochondrial transcription factors B1 and
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