SRP6059
Progranulin from mouse
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
PC cell-derived growth factor, PEPI, Proepithelin
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
mouse
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
~70.0 kDa
packaging
pkg of 10 μg
manufacturer/tradename
Sigma-Aldrich
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... GRN(10090)
General description
tumor suppression and are expressed in a cell-specific manner. Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SERPINE1 and
Physical form
0.2 μm-filtered solution in PBS
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
Signal peptide and mouse Progranulin (aa 1-589) fused at the C-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury
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