SRP6055
Granzyme A human
recombinant, expressed in mammalian cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in mammalian cells
assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
26.9 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GZMA(3001)
General description
Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).
Physical form
Lyophilized from a 0.2 μm filtered solution of 20 mM MES and150 mM NaCl, pH 5.5.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitution
Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). This can further be diluted to other aqueous buffers.
Other Notes
Recombinant Human Granzyme A is produced with mammalian cells expression system. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme a (Uniprot #P12544) fused with a polyhistidine tag at the C-terminus.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Experimental eye research, 134, 1-14 (2015-03-11)
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Neurobiology of aging, 36(12), 3214-3227 (2015-10-11)
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15649-15665 (2015-11-27)
Cell therapy demonstrates great potential for the treatment of neurological disorders. Human umbilical tissue-derived cells (hUTCs) were previously shown to have protective and regenerative effects in animal models of stroke and retinal degeneration, but the underlying therapeutic mechanisms are unknown.
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