SRP6031

BMPR1A human

recombinant, expressed in Insect cells (Baculovirus), ≥90% (SDS-PAGE), ≥90% (HPLC)

• Synonym(s): BMP-R1A, BMPR-1A, BMPR1A, BMR1A, CD292
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in Insect cells (Baculovirus)
• assay: ≥90% (HPLC); ≥90% (SDS-PAGE)
• form: lyophilized
• mol wt: 23.0 kDa
• packaging: pkg of 10 μg
• impurities: Endotoxin, tested
• NCBI accession no.: P36894
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... BMPR1A(657)

Description

General description

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the Activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.

Physical form

Lyophilized from sterile PBS.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable