SRP5269

HDAC7, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): DKFZp586J0917, FLJ99588, HD7A, HDAC7A
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• recombinant: expressed in baculovirus infected Sf9 cells
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 64-96 RLU/min·ng
• mol wt: ~80 kDa
• NCBI accession no.: NM_015401
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... HDAC7(51564)

Description

General description

HDAC7 or Histone deacetylase 7 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by HDAC7 gene has sequence homology to members of the histone deacetylase family whose protein promotes repression mediated via the transcriptional co-repressor SMRT. HDAC7 interacts with β-catenin keeping endothelial cells in a low proliferation stage. HDAC7 regulates NUR77 and apoptosis in developing thymocytes. HDAC7 is expressed in human osteoarthritis that contributes to cartilage degradation via promoting MMP-13 gene expression.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable