SRP5121
RAC1, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
MGC111543, MIG5, TC-25, p21-Rac1
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About This Item
biological source
human
recombinant
expressed in E. coli
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~47 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RAC1(5879)
General description
RAC1 is a member of the Rho family and is a GTPase that is part of the small GTP-binding protein superfamily. RAC1 is involved in a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Role of RAC1 in colorectal cancer has been reported after analysis of the protein expression level and activities of this protein in matched sets of tumor and non-tumor tissues. Overexpression of RAC1 leads to increased tumour growth in xenografts of human colorectal tumour cells. RAC1 is also involved in the regulation of critical cellular functions including organization of actin cytoskeleton, transcription control and cell cycle.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Teresa Gómez del Pulgar et al.
The international journal of biochemistry & cell biology, 39(12), 2289-2302 (2007-09-04)
The small GTPase Rac1 is involved in the regulation of critical cellular functions, such as transcription control, cell cycle, and organization of actin cytoskeleton. Rac1 signalling modulates cancer progression since its overexpression leads to an increased tumour growth of xenografts
Yoji Takami et al.
Digestive diseases and sciences, 53(2), 467-473 (2007-06-29)
Rho family GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. To evaluate the role of these GTPases in colorectal cancer, the protein expression levels and activities of these proteins in
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