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SRP4667

Sigma-Aldrich

GDF-5 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

CDMP-1, Cartilage-Derived Morphogenetic Protein-1, Cartilage-derived morphogenetic protein-1, LAP4, Radotermin, SYNS2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

~26.8 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P43026

UniProt accession no.

P43026

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GDF5(8200)

General description

GDF-5 acts as an inhibitor of nerve tissue growth. It is produced as a homodimer, non-glycosylated polypeptide chain containing 2 X 117 amino acids with a molecular weight of 26.8 kDa. To enable bacterial expression of rhGDF-5 we removed the N-terminal sequence Ala-Pro- Leu- Thr and added the Lys.

Physical form

Sterile filtered and Lyophilized without additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 20 Mm HOAc to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
50967

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Chunfeng Zhao et al.
Clinical orthopaedics and related research, 472(9), 2569-2578 (2014-06-08)
Adhesions and poor healing are complications of flexor tendon repair. The purpose of this study was to investigate a tissue engineering approach to improve functional outcomes after flexor tendon repair in a canine model. Flexor digitorum profundus tendons were lacerated
Zhou Pei et al.
Archives of biochemistry and biophysics, 560, 27-35 (2014-08-01)
Adipocyte differentiation is key to determining the number of adipocytes during the development of obesity. Recent studies have shown that growth differentiation factor-5 (GDF5) promotes brown adipogenesis, however its role in white adipogenesis is still uncertain. The aim of the

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