SRP4657

Gremlin 2 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Synonym(s): BMP antagonist 2, Cysteine knot superfamily 1, DAN domain family member 3, Gremlin-2, Protein related to DAN and cerberus
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥95% (HPLC); ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~17.2 kDa
• packaging: pkg of 20 μg
• impurities: endotoxin, tested
• NCBI accession no.: Q9H772
• UniProt accession no.: Q9H772
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... GREM2(64388)

Description

General description

Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli.

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute to 1 mg/mL with sterilized dH₂O. Pipette to dissolve the protein pellet completely.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable