SRP4571
EG-VEGF human
recombinant, expressed in mouse cell line, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
Endocrine-gland-derived vascular endothelial growth factor, PROK1, Prokineticin-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in mouse cell line
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~9.5 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Storage temp.
−20°C
Gene Information
human ... PROK1(84432)
General description
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) belongs to the prokineticin family. It is mainly expressed in the steroidogenic glands (ovary, testis, adrenal cortex and placenta). EG-VEGF is a small, secreted peptide and works as a tissue-specific pro-angiogenic mitogen and chemotactic agent. The gene is mapped to human chromosome 1p13.[1][2]
Biochem/physiol Actions
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is involved in angiogenesis, inflammatory responses and hematopoiesis. It also participates in female reproduction. EG-VEGF suppresses trophoblast invasion in pregnancy. Changes in the activity of this protein are associated with gestational complication, such as gestational trophoblastic diseases, repeated pregnancy losses, preeclampsia and intrauterine fetal growth restriction. EG-VEGF interacts with G protein-coupled receptors, prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). It is also involved in the pathology of Leydig-cell-tumors, papillary thyroid cancer, neuroblastoma, prostate cancer, gastrointestinal tumors, pancreatic ductal adenocarcinoma, Merkel cell carcinoma and multiple myeloma.[1][3]
Physical form
Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile PBS to a concentration of 0.1-1.0 mg/mL containing 0.1% BSA. This solution can then be diluted into other aqueous buffers
Certificates of Analysis (COA)
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A Common Variant of PROK1 (V67I) Acts as a Genetic Modifier in Early Human Pregnancy through Down-Regulation of Gene Expression.
Su MT
International Journal of Molecular Sciences (2016)
Hirschsprung's disease as a model of complex genetic etiology.
Borrego S
Histology and Histopathology (2013)
Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
Heck D
Hormones & Cancer (2015)
Sharon L Eddie et al.
The Journal of clinical endocrinology and metabolism, 100(9), E1197-E1205 (2015-07-21)
Fetal ovarian development and primordial follicle formation underpin future female fertility. Prokineticin (PROK) ligands regulate cell survival, proliferation, and angiogenesis in adult reproductive tissues including the ovary. However, their expression and function during fetal ovarian development remains unclear. This study
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