SRP4244
MIP-1alpha human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
G0S19-1, LD78α, MIP-1-α, chemokine (C-C motif) ligand 3
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About This Item
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~7.8 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CCL3(6348)
General description
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), was originally isolated from the supernatant of endotoxin-stimulated murine macrophages. It is an 8kDa chemokine; chemokines are a type of chemotactic cytokines.[1]
Biochem/physiol Actions
MIP-1α (microphage inflammatory protein-1α), or CCL3 (C-C motif chemokine ligand 3), and its receptors- CCR1 and CCR5- promote tumor growth and control osteoclast differentiation, thereby contributing to bone disease progression in multiple myeloma. It suppresses the expression of miR-374b through JNK (Janus kinase), ERK (extracellular signal-regulated kinases), and p38 pathways, thus, facilitating VEGF-A (vascular endothelial growth factor) expression and angiogenesis in human osteosarcoma cells. In chondrosarcoma cells, this protein promotes the up-regulation of matrix metalloproteinase-2 (MMP)-2, thus, promoting cell migration and metastasis.[2]
Physical form
Sterile filtered and then lyophilized without any additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can be diluted into other aqueous buffers.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells.
Liao YY et al
Oncotarget, 7(4), 4310-4325 (2016)
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Zhang N et al
Proceedings of the National Academy of Sciences of the USA, 102(12), 4536-4541 (2005)
Ping Shi et al.
Oncology reports, 34(3), 1319-1326 (2015-07-03)
In recent years, astrocyte elevated gene-1 (AEG-1) has been reported as a key mediator that is involved in the epithelial-to-mesenchymal transition (EMT) process. However, the mechanisms underlying CCL3/CCR5-AEG-1 pathway-mediated EMT in cardiac myxoma (CM) has not been well featured till
Katsuyuki Matsushita et al.
Anesthesiology, 120(6), 1491-1503 (2014-03-05)
The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C
Inger Øynebråten et al.
PloS one, 9(8), e104814-e104814 (2014-08-15)
DNA vaccines based on subunits from pathogens have several advantages over other vaccine strategies. DNA vaccines can easily be modified, they show good safety profiles, are stable and inexpensive to produce, and the immune response can be focused to the
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