SRP4172
IL-15 from rat
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
IL 15, IL-T, Interleukin 15
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About This Item
biological source
rat
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
<5 ng/mL
mol wt
~13.5 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Il15(25670)
General description
IL-15 stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues
Physical form
Sterile filtered and lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 50 mM Tris, pH 8.5 to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.
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Pravin Kesarwani et al.
Cancer research, 74(21), 6036-6047 (2014-08-29)
Ex vivo-expanded CD8(+) T cells used for adoptive immunotherapy generally acquire an effector memory-like phenotype (TEM cells). With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited persistence and reduced antitumor efficacy, relative to CD8(+)
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