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Key Documents

SRP4028

Sigma-Aldrich

Eotaxin human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Synonym(s):

CCL11, Eosinophil chemotactic protein chemokine (C-C motif) ligand 11, MGC22554, SCYA11, Small inducible cytokine A11

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About This Item

MDL number:
MFCD01093487
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥97% (HPLC)
≥97% (SDS-PAGE)

form

lyophilized

potency

10 ng/mL

mol wt

~8.3 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P51671

UniProt accession no.

P51671

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CCL11(6356)

General description

Eotaxin is a chemokine and belongs to the Th2 (T helper 2) cytokine family. It is expressed in many organs, such as heart, central nervous system and the cerebrospinal fluid. The associated gene (CCL11 (C-C motif chemokine ligand 11)) is mapped to human chromosome 17q12.

Biochem/physiol Actions

Eotaxin participates in immunoregulatory and inflammatory responses. It works as a chemoattractant for many immune cells, including eosinophils, basophils, myeloid cells and T-helper 2 lymphocytes. The eotaxin gene is associated with atopic dermatitis, allergic rhinitis, sinusitis, asthma, ulcerative colitis, gastrointestinal disorders and parasitic infections. It is also involved with the pathogenesis of ovarian and gastric cancer. Eotaxin plays a significant role in the aging processes.

Physical form

Sterile filtered and Lyophilized without additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstituted in water to a concentration of 0.1-1 μg/μL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
70128
61128

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Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death.
Kandasamy J, et al.
Pediatric Research, 78, 498-498 (2015)
Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.
Waddell A, et al.
Journal of Immunology, 186, 5993-5993 (2011)
Letícia Lintomen et al.
BMC pulmonary medicine, 8, 13-13 (2008-08-14)
Airway eosinophilia is considered a central event in the pathogenesis of asthma. The toxic components of eosinophils are thought to be important in inducing bronchial mucosal injury and dysfunction. Previous studies have suggested an interaction between nitric oxide (NO) and
Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines.
Bostrom EA, et al.
PLoS ONE, 10, e0134608-e0134608 (2015)
Kimberly D Dyer et al.
PloS one, 10(3), e0118887-e0118887 (2015-03-17)
HMGB1 is an alarmin that can stimulate the innate immune system alone or in a complex with other inflammatory mediators. Given the recent interest in HMGB1 with respect to the pathogenesis of eosinophil-associated disorders, including asthmatic inflammation and chronic rhinosinusitis
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