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SRP3180

Sigma-Aldrich

TWEAK Receptor human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

FGF-inducible 14, TNF-related weak inducer of apoptosis receptor, TNFRSF12A

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25 μG
$367.00

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25 μG
$367.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

$367.00

Usually ships in 2 weeks.
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biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

1.0-3.0 μg/mL ED50

mol wt

5.6 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q9NP84

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TNFRSF12A(51330)

General description

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell′s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

Biochem/physiol Actions

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell′s apoptotic machinery. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

Sequence

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 50 mM NaCl.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0503275-1

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A Kaptein et al.
FEBS letters, 485(2-3), 135-141 (2000-11-30)
WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine
S R Wiley et al.
Immunity, 15(5), 837-846 (2001-12-01)
TWEAK is a member of the TNF ligand family that induces angiogenesis in vivo. We report cloning of a receptor for TWEAK (TweakR) from a human umbilical vein endothelial cell (HUVEC) library. The mature form of TweakR has only one

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