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10 μG
$456.00
$456.00
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10 μG
$456.00
About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
$456.00
Usually ships in 2 weeks.
recombinant
expressed in baculovirus infected Sf9 cells
assay
70-95% (SDS-PAGE)
form
frozen liquid
specific activity
70-100 nmol/min·mg (radiometric)
mol wt
~77 kDa
concentration
0.05-0.1 μg/μL
accession no.
BC008838
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MEK5(5607)
Application
Useful for kinase assay and Western blot.
Biochem/physiol Actions
Recombinant full-length human MEK5 was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. MEK5 or MAP2K5 (mitogen-activated protein kinase kinase 5) is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MEK5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MEK5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation (1). The rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer (CRC) (2).
Reconstitution
Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
Storage and Stability
Store in aliquots at -70°C. Avoid freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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