assay
≥95% (HPLC)
form
aqueous solution
mol wt
2765.3 kDa
packaging
pkg of 5 mL
shipped in
dry ice
storage temp.
−20°C
General description
The Bromodomain Ligand 2 is peptide histone H3 (1-21), acetylated at lysine 14. It contains a C-terminal GG linker, followed by a biotinylated Lys. Bromodomains function as acetyl-lysine binding domains, and bromodomain/acetyl-lysine recognition can regulate histone modification, DNA replications, chromatin remodeling, and gene transcription. This peptide is suitable for use as a ligand for several bromodomains including ATAD2 and BAZ2B.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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C A Johnson et al.
Nucleic acids research, 26(4), 994-1001 (1998-03-21)
The pattern of histone H4 acetylation in different genomic regions has been investigated by immunoprecipitating oligonucleosomes from a human lymphoblastoid cell line with antibodies to H4 acetylated at lysines 5, 8, 12 or 16. DNA from antibody-bound or unbound chromatin
Z Jasencakova et al.
The Plant cell, 12(11), 2087-2100 (2000-11-23)
Reversible acetylation of nucleosomal histones H3 and H4 generally is believed to be correlated with potential transcriptional activity of eukaryotic chromatin domains. Here, we report that the extent of H4 acetylation within euchromatin and heterochromatic domains is linked with DNA
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