SRP0431
PDE4D7 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥65% (SDS-PAGE)
Synonym(s):
DPDE3, PDE43, STRK1, phosphodiesterase 4D, cAMP-specific
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥65% (SDS-PAGE)
form
aqueous solution
mol wt
111 kDa
packaging
pkg of 5 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PDE4D(5144)
General description
Human PDE4D7 (GenBank Accession No. NM_001165899) amino acids 2-748 (end) with N-terminal GST-tag, MW=111 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Miles D Houslay
Molecular pharmacology, 68(3), 563-567 (2005-06-17)
In this issue, Tilley and Maurice (p. 596) show that differentiation of vascular smooth muscle cells to a proliferative phenotype is associated with a profound up-regulation of specific phosphodiesterase-4 (PDE4) isoforms because of increased histone acetylation. The increased PDE4 activity
Daguang Wang et al.
Cellular signalling, 15(9), 883-891 (2003-07-02)
We report here the cloning and characterization of two novel PDE4D isoforms, PDE4D6 and PDE4D7. PDE4D6 is a supershort form and PDE4D7 a long form of PDE4D. In addition, we have identified another novel long-form variant, PDE4D8, in silico. Like
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