SRP0422
PARP5A active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)
Synonym(s):
PARP5a, TNKS1, Tankyrase1, poly(ADP-ribosyl)transferase 5a
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10 μG
$601.00
About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥30% (SDS-PAGE)
form
aqueous solution
mol wt
62.5 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TNKS(8658)
General description
TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), amino acids 1000-1328 (end) with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sandy Chang
Aging, 2(10), 639-642 (2010-11-16)
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates
N McCabe et al.
Oncogene, 28(11), 1465-1470 (2009-02-03)
The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other organs. It has been demonstrated previously that inhibiting
Courtney M Karner et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 239(7), 2014-2023 (2010-06-16)
Recent studies using small molecule antagonists have revealed that the poly(ADP-ribose) polymerases (PARPs) Tankyrase 1 and 2 are critical regulators of canonical Wnt signaling in some cellular contexts. However, the absence of any activity during zebrafish embryogenesis suggested that the
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