SRP0398
Histone H3 peptide (Di-methylated K9), biotin
≥95% (HPLC)
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
assay
≥95% (HPLC)
form
aqueous solution
packaging
pkg of 500 μL
concentration
40 μM
shipped in
dry ice
storage temp.
−70°C
General description
The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)2. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A).[1][2][3] Dimethylated histone H3 lysine 9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas.[4]
Application
Study enzyme kinetics, and screen small molecular inhibitors of JMJ for drug discovery and HTS applications.
Biochem/physiol Actions
Histone proteins are basic building blocks of chromatin.[5] Post-translational modifications of histone tails controls chromatin organization and gene transcription. Histone H3 lysine 9 dimethylation (H3K9me2) serves as an epigenetic marker for gene repression and silencing. This modification plays a significant role in embryogenesis and carcinogenesis. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells[4]
Other Notes
500 μL at 40 μM, or 20 nmol Sold as 500 μL
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin.
Lehnertz B, et al.
Current Biology, 13, 1192-1192 (2003)
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
Arents G and Moudrianakis EN
Proceedings of the National Academy of Sciences of the USA, 90, 10489-10489 (1993)
Shiv I S Grewal et al.
Current opinion in cell biology, 16(3), 230-238 (2004-05-18)
Heterochromatin mediates various nuclear processes including centromere function, gene silencing and nuclear organization. Although it was discovered nearly 75 years ago, the pathways involved in heterochromatin establishment, assembly and epigenetic maintenance have been elusive. Recent reports have demonstrated that distinct
Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients.
Zhang L, et al.
American Journal of Nephrology, 30, 505-505 (2009)
Signaling to chromatin through histone modifications.
P Cheung et al.
Cell, 103(2), 263-271 (2000-11-01)
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
