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Key Documents

SRP0370

Sigma-Aldrich

MUSK active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonym(s):

muscle, skeletal, receptor tyrosine kinase

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About This Item

CAS Number:
176591-32-5
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

aqueous solution

mol wt

38.5 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.11 mg/mL

technique(s)

activity assay: suitable
inhibition assay: suitable

NCBI accession no.

NM_005592

UniProt accession no.

O15146

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MUSK(4593)

General description

Human MUSK (GenBank Accession No. NM_005592), amino acids 530-end with N-terminal His-tag, MW = 38.5 kDa, expressed in Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
4007990106

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Amelia Evoli et al.
Annals of the New York Academy of Sciences, 1132, 76-83 (2008-06-24)
Myasthenia gravis (MG) with antibodies against the muscle-specific tyrosine kinase (MuSK abs) is often a severe disease requiring aggressive treatment. Various immunosuppressive (IS) regimens have been employed; the efficacy of plasma exchange is unanimously recognized, while the indication for thymectomy
H Zhou et al.
The Journal of cell biology, 146(5), 1133-1146 (1999-09-09)
Agrin released from motor nerve terminals activates a muscle-specific receptor tyrosine kinase (MuSK) in muscle cells to trigger formation of the skeletal neuromuscular junction. A key step in synaptogenesis is the aggregation of acetylcholine receptors (AChRs) in the postsynaptic membrane

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