Human AE binding protein 2 (AEBP2), (GenBank Accession No. NM_153207), amino acids 2-503 (end) with N-terminal His-tag, MW=53.6 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Aebp2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2). We generated a mutant mouse line disrupting the transcription of Aebp2 to investigate its in vivo roles. Aebp2-mutant homozygotes were embryonic lethal while heterozygotes survived to
Recent studies have revealed the intrinsic histone methyltransferase (HMTase) activity of the EED-EZH2 complex and its role in Hox gene silencing, X inactivation, and cancer metastasis. In this study, we focus on the function of individual components. We found that
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