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SML2909

Sigma-Aldrich

Nolatrexed dihydrochloride

≥98% (HPLC)

Synonym(s):

2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride, AG 337

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$78.18
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$268.00

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5 MG
$78.18
25 MG
$268.00

About This Item

Empirical Formula (Hill Notation):
C14H12N4OS · 2HCl
CAS Number:
152946-68-4
Molecular Weight:
357.26
MDL number:
MFCD26960887
UNSPSC Code:
12352200
NACRES:
NA.77

$78.18

List Price$82.30Save 5%
Web-Only Promotion

Available to ship onApril 30, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O

InChI

1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H

InChI key

PJKVJJYMWOCLIJ-UHFFFAOYSA-N

Biochem/physiol Actions

Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.
potent thymidylate synthase inhibitor

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A N Hughes et al.
British journal of cancer, 82(9), 1519-1527 (2000-05-02)
A clinical study of nolatrexed dihydrochloride (AG337, Thymitaq) in combination with paclitaxel was performed. The aims were to optimize the schedule of administration and determine any pharmacokinetic (PK) interactions between the two drugs. In vitro combination studies were performed to
Simon Dewar et al.
The Journal of biological chemistry, 291(47), 24768-24778 (2016-10-21)
The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate and raltitrexed. In conjunction with
Dan Chen et al.
The Journal of biological chemistry, 292(32), 13449-13458 (2017-06-22)
Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Inhibition of human TS (hTS) has been extensively investigated for cancer chemotherapy, but several aspects of its

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