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SML2831

Sigma-Aldrich

VU041

≥98% (HPLC)

Synonym(s):

1,2,3,4-Tetrahydro-1-[[4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-1-yl]acetyl]-quinoline, 1-(3,4-Dihydroquinolin-1(2H)-yl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)ethan-1-one, VU0048041

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$88.82
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5 MG
$88.82
25 MG
$301.00

About This Item

Empirical Formula (Hill Notation):
C19H20F3N3O
CAS Number:
332943-64-3
Molecular Weight:
363.38
UNSPSC Code:
12352200
NACRES:
NA.77

$88.82

List Price$93.50Save 5%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CN1N=C(C2=C1CCCC2)C(F)(F)F)N3CCCC4=C3C=CC=C4

InChI

1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2

InChI key

DLAGRCZUELSZFG-UHFFFAOYSA-N

Biochem/physiol Actions

VU041 is a mosquito cuticle penetrant, potent and selective inhibitor of inwardly rectifying potassium (Kir) channel of Aedes aegypti (AeKir1) and Anopheles gambiae (AnKir1) that exhibits potent toxicity to adult insecticide-susceptible and -resistant strains of female mosquitoes. VU041 is selective for mosquito Kir channels over several mammalian orthologs. Also, VU041 is toxic to mosquito larvae when present in water.
mosquito cuticle penetrant, potent and selective inhibitor of Kir channel of Aedes aegypti and Anopheles gambiae; selective for mosquito Kir channels over several mammalian orthologs

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Renata Rusconi Trigueros et al.
Insects, 9(4) (2018-11-18)
The inward rectifier potassium (Kir) channels play key roles in the physiology of mosquitoes and other insects. Our group, among others, previously demonstrated that small molecule inhibitors of Kir channels are promising lead molecules for developing new insecticides to control
Zhilin Li et al.
Pest management science, 75(10), 2725-2734 (2019-02-21)
The unique feeding biology of aphids suggests novel insecticide targets are likely to exist outside of the nervous system. We therefore aimed to directly test the hypothesis that pharmacological inhibition of inward rectifier potassium (Kir) channels would result in salivary
Daniel R Swale et al.
Scientific reports, 6, 36954-36954 (2016-11-17)
Insecticide resistance is a growing threat to mosquito control programs around the world, thus creating the need to discover novel target sites and target-specific compounds for insecticide development. Emerging evidence suggests that mosquito inward rectifier potassium (Kir) channels represent viable

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