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Key Documents

SML2798

Sigma-Aldrich

CH625

≥98% (HPLC)

Synonym(s):

(2E)-1-(4-Hydroxy-2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,4′-Dihydroxy-2′,6′-dimethoxychalcone, ZINC95910725

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$62.60
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$268.00

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5 MG
$62.60
25 MG
$268.00

About This Item

Empirical Formula (Hill Notation):
C17H16O5
CAS Number:
123316-64-3
Molecular Weight:
300.31
UNSPSC Code:
51111800
NACRES:
NA.77

$62.60

List Price$65.90Save 5%
Web-Only Promotion

Available to ship onMay 01, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

Storage temp.

2-8°C

Biochem/physiol Actions

CH625 is a potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in glioma intracranial and subcutaneous model in rats. CH625 normalizes tumor vasculature in the C6 and GL261 gliomas through tumor-associated macrophages (TAMs) reprograming and inhibition of VEGF and TGF-β production.
potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in gliomas

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000119371
0000119372
0000109348

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Chenlong Wang et al.
The Journal of pharmacology and experimental therapeutics, 365(1), 72-83 (2018-02-14)
Tumor-associated macrophages (TAMs) are pivotal effector cells in angiogenesis. Here, we tested whether CYP4X1 inhibition in TAMs by flavonoid CH625 prolongs survival and normalizes glioma vasculature. CH625 was selected against the CYP4X1 3D model by virtual screening and showed inhibitory

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