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SML2701

Sigma-Aldrich

CBA

≥98% (HPLC)

Synonym(s):

4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid

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5 MG
$50.24
25 MG
$215.00

About This Item

Empirical Formula (Hill Notation):
C15H11Cl2NO4
CAS Number:
351424-20-9
Molecular Weight:
340.16
MDL number:
MFCD01930120
UNSPSC Code:
12352200
NACRES:
NA.77

$50.24

List Price$53.00Save 5%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1c(cccc1)OCC(=O)Nc2c(ccc(c2)Cl)C(=O)O

InChI

1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)

InChI key

CVQCJPCMPGKEDH-UHFFFAOYSA-N

Biochem/physiol Actions

CBA (Compound 5; 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid) is a cell penetrant, potent and selective TRPM4 (Transient receptor potential melastatin member 4) inhibitor that shows not significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6. It rescues functional expression of mutant A432T TRPM4 in cells. CBA (Compound 5) exhibits neuroprotective activity against glutamate-induced neurodegeneration.
cell penetrant, potent and selective TRPM4 (Transient receptor potential melastatin member 4) inhibitor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Beatrice Bianchi et al.
Molecular brain, 11(1), 41-41 (2018-07-13)
Transient receptor potential melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel, has been found to mediate cell membrane depolarization in immune response, insulin secretion, cardiovascular diseases, and cancer. In murine experimental autoimmune encephalomyelitis (EAE), TRPM4 deletion and administration of
Lijo Cherian Ozhathil et al.
British journal of pharmacology, 175(12), 2504-2519 (2018-03-27)
TRPM4 is a calcium-activated non-selective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors. We sought to discover a

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